2025 Fantasy Football Running Back Handcuffs

Injuries happen frequently in the NFL. When a starter goes down, the backup almost instantly becomes fantasy-relevant. Knowing which players are likely to see the injury bug can help when planning for a late-round draft pick and avoid the Waiver Wire rush.

Injury Risk Level
Low
Medium
High

Arizona Cardinals

Arizona
1. James Conner
2. Trey Benson Handcuff

Atlanta Falcons

Atlanta
1. Bijan Robinson
2. Tyler Allgeier Handcuff

Baltimore Ravens

Baltimore
1. Derrick Henry
2. Justice Hill Handcuff

Buffalo Bills

Buffalo
1. James Cook
2. Ray Davis Handcuff

Carolina Panthers

Carolina
1. Chuba Hubbard
2. Rico Dowdle Handcuff

Chicago Bears

Chicago
1. D'Andre Swift
2. Roschon Johnson Handcuff

Cincinnati Bengals

Cincinnati
1. Chase Brown
2. Zack Moss Handcuff

Cleveland Browns

Cleveland
1. Jerome Ford
2. Quinshon Judkins Handcuff

Dallas Cowboys

Dallas
1. Javonte Williams
2. Miles Sanders Handcuff

Denver Broncos

Denver
1. Audric Estime
2. Jaleel McLaughlin Handcuff

Detroit Lions

Detroit
1. Jahmyr Gibbs
2. David Montgomery Handcuff

Green Bay Packers

Green Bay
1. Josh Jacobs
2. Emanuel Wilson Handcuff

Houston Texans

Houston
1. Joe Mixon
2. Dameon Pierce Handcuff

Indianapolis Colts

Indianapolis
1. Jonathan Taylor
2. Khalil Herbert Handcuff

Jacksonville Jaguars

Jacksonville
1. Travis Etienne
2. Tank Bigsby Handcuff

Kansas City Chiefs

Kansas City
1. Isiah Pacheco
2. Kareem Hunt Handcuff

Los Angeles Chargers

L.A. Chargers
1. Najee Harris
2. Omarion Hampton Handcuff

Los Angeles Rams

L.A. Rams
1. Kyren Williams
2. Blake Corum Handcuff

Las Vegas Raiders

Las Vegas
1. Ashton Jeanty
2. Zamir White Handcuff

Miami Dolphins

Miami
1. Devon Achane
2. Alexander Mattison Handcuff

Minnesota Vikings

Minnesota
1. Aaron Jones
2. Jordan Mason Handcuff

New England Patriots

New England
1. Rhamondre Stevenson
2. TreVeyon Henderson Handcuff

New Orleans Saints

New Orleans
1. Alvin Kamara
2. Kendre Miller Handcuff

N.Y. Giants

N.Y. Giants
1. Tyrone Tracy
2. Devin Singletary Handcuff

N.Y. Jets

N.Y. Jets
1. Breece Hall
2. Braelon Allen Handcuff

Philadelphia Eagles

Philadelphia
1. Saquon Barkley
2. AJ Dillon Handcuff

Pittsburgh Steelers

Pittsburgh
1. Jaylen Warren
2. Kaleb Johnson Handcuff

Seattle Seahawks

Seattle
1. Kenneth Walker
2. Zach Charbonnet Handcuff

San Francisco 49ers

San Francisco
1. Christian McCaffrey
2. Isaac Guerendo Handcuff

Tampa Bay Buccaneers

Tampa Bay
1. Bucky Irving
2. Rachaad White Handcuff

Tennessee Titans

Tennessee
1. Tony Pollard
2. Tyjae Spears Handcuff

Washington Commanders

Washington
1. Brian Robinson
2. Austin Ekeler Handcuff