James Cook

Cook rushed 22 times for 107 yards and two touchdowns while bringing in two of three targets for four yards and another score in the Bills' 35-31 win over the Patriots on Sunday.

The Patriots' rushing defense has struggled since Milton Williams (ankle) was placed on the IR. James Cook took advantage of that on Sunday, consistently earning hard yards up the gut and then using a tremendous second-effort dive to get his first rushing touchdown. Cook was targeted three times in the passing game, but was kept in check apart from his five-yard touchdown catch (yes, you read that right). The Bills will need Cook again against a tough Browns defense next week in what should be another freezing, cold game.

Which matchups will determine the outcome of the Patriots-Bills Week 15 showdown? Phil Perry explains in his in-depth preview.

While the 49ers might not be as well represented as years past at the 2026 NFL Pro Bowl Games, San Francisco still has a couple of notable players who currently are earning a large portion of fan voting. Running back Christian McCaffrey leads his position in fan voting, with the 2023 NFL Offensive Player of the Year pacing fellow star ball carriers Jonathan Taylor (Indianapolis Colts), Jahmyr Gibbs (Detroit Lions), Bijan Robinson (Atlanta Falcons) and James Cook (Buffalo Bills).

Cook carried the ball 18 times for 80 yards and caught both his targets for 31 yards in Sunday's 39-34 win over the Bengals.