Week 4 NFL Picks: Jacksonville Jaguars at San Francisco 49ers
NFL Picks for Jaguars / 49ers game
Consensus Pick
Consensus Total Picks
Game Info
Home Team: San Francisco (3 - 0)
Away Team: Jacksonville (2 - 1)
Game Day: Sunday, Sep 28, 2025
Kickoff: 4:05 PM ET
Station: FOX
Projected Score: 
24 
22
Winner: 49ers
Over/Under: 45.5
Spread: 104.0
| Organization | Expert | Expert Rank | Expert Pick |
|---|---|---|---|
| WXIX-TV |  Regan Holgate |
1 | |
| CBS Sports |  Pete Prisco |
2 | |
| CBS Sports |  Jamey Eisenberg |
3 | |
| CBS Sports | Ryan Wilson | 4 | |
| FanDuel | FanDuel | 5 | |
| ESPN | Mike Clay | 7 | |
| ESPN | Jason Reid | 6 | |
| CBS Sports | Cody Benjamin | 8 | |
| ESPN | Lindsey Thiry | 9 | |
| CBS Sports | Dave Richard | 10 | |
| DraftKings | DraftKings | 11 | |
| The Sports Affiliation | Greg Kellogg | 12 | |
| ESPN | Matt Bowen | 13 | |
| CBS Sports | John Breech | 14 | |
| ESPN | Jeremy Fowler | 15 | |
| CBS Sports | Jared Dubin | 16 | |
| ESPN | Seth Wickersham | 18 | |
| ESPN | Eric Moody | 17 | |
| ESPN | Pamela Maldonado | 19 | |
| CBS Sports | Tyler Sullivan | 20 | |
| ESPN | Stephania Bell | 21 | |
| Fox 13 Seattle | Ethan McReynolds | 22 | |
| ESPN | Kalyn Kahler | 23 | |
| Yahoo Sports | Yahoo Users | 24 | |
| ESPN | Dan Graziano | 25 | |
| USA Today | Steve Gardner | 26 | |
| Denver7 | Nick Rothschild | 27 | |
| GoingFor2.com | Geoff Lambert | 28 | |
| Associated Press | Joe Reedy | 29 | |
| WKBW-TV | Dom Tibbetts | 30 | |