Week 16 NFL Picks: San Francisco 49ers at Indianapolis Colts
NFL Picks for 49ers / Colts game
Consensus Pick
Consensus Total Picks
Game Info
Home Team: Indianapolis (8 - 6)
Away Team: San Francisco (10 - 4)
Game Day: Monday, Dec 22, 2025
Kickoff: 8:15 PM ET
Station: ESPN
Projected Score: 
21 
25
Winner: 49ers
Over/Under: 46.5
Spread: -110.0
| Organization | Expert | Expert Rank | Expert Pick |
|---|---|---|---|
| FanDuel |  FanDuel |
1 | |
| WXIX-TV |  Regan Holgate |
2 | |
| CBS Sports | Pete Prisco | 4 | |
| DraftKings |  DraftKings |
3 | |
| ESPN | Jason Reid | 5 | |
| CBS Sports | John Breech | 7 | |
| ESPN | Lindsey Thiry | 9 | |
| CBS Sports | Ryan Wilson | 8 | |
| ESPN | Jeremy Fowler | 6 | |
| CBS Sports | Dave Richard | 13 | |
| ESPN | Mike Clay | 10 | |
| ESPN | Matt Bowen | 11 | |
| CBS Sports | Tyler Sullivan | 12 | |
| CBS Sports | Cody Benjamin | 14 | |
| The Sports Affiliation | Greg Kellogg | 15 | |
| ESPN | Eric Moody | 16 | |
| ESPN | Seth Wickersham | 17 | |
| ESPN | Pamela Maldonado | 19 | |
| ESPN | Stephania Bell | 18 | |
| USA Today | Steve Gardner | 20 | |
| CBS Sports | Jared Dubin | 21 | |
| ESPN | Kalyn Kahler | 22 | |
| ESPN | Dan Graziano | 23 | |
| Denver7 | Nick Rothschild | 24 | |
| Yahoo Sports | Yahoo Users | 25 | |
| Fox 13 Seattle | Ethan McReynolds | 26 | |