Week 1 NFL Picks: San Francisco 49ers at Seattle Seahawks
NFL Picks for 49ers / Seahawks game
Consensus Pick
Consensus Total Picks
Game Info
Home Team: Seattle (0 - 0)
Away Team: San Francisco (0 - 0)
Game Day: Sunday, Sep 7, 2025
Kickoff: 4:05 PM ET
Station: FOX
Projected Score: 
18 
19
Winner: 49ers
Over/Under: 43.5
Spread: -110.0
| Organization | Expert | Expert Rank | Expert Pick |
|---|---|---|---|
| WXIX-TV | Regan Holgate | - | |
| CBS Sports | Pete Prisco | - | |
| CBS Sports | Jamey Eisenberg | - | |
| CBS Sports | Ryan Wilson | - | |
| FanDuel | FanDuel | - | |
| ESPN | Mike Clay | - | |
| ESPN | Jason Reid | - | |
| CBS Sports | Cody Benjamin | - | |
| ESPN | Lindsey Thiry | - | |
| CBS Sports | Dave Richard | - | |
| DraftKings | DraftKings | - | |
| The Sports Affiliation | Greg Kellogg | - | |
| ESPN | Matt Bowen | - | |
| CBS Sports | John Breech | - | |
| ESPN | Jeremy Fowler | - | |
| CBS Sports | Jared Dubin | - | |
| ESPN | Eric Moody | - | |
| ESPN | Pamela Maldonado | - | |
| ESPN | Seth Wickersham | - | |
| CBS Sports | Tyler Sullivan | - | |
| ESPN | Stephania Bell | - | |
| Fox 13 Seattle | Ethan McReynolds | - | |
| ESPN | Kalyn Kahler | - | |
| Yahoo Sports | Yahoo Users | - | |
| ESPN | Dan Graziano | - | |
| USA Today | Steve Gardner | - | |
| Denver7 | Nick Rothschild | - | |
| GoingFor2.com | Geoff Lambert | - | |
| Associated Press | Joe Reedy | - | |
| WKBW-TV | Dom Tibbetts | - | |
| NBC 26 | John Miller | - | |
| FOX 13 Tampa Bay | Scott Smith | - | |
| NBC 26 | Kelly Hallinan | - | |
| Spectrum Sports | Mike Cairns | - | |
| WXIX-TV | Jeremy Rauch | - | |