This is the Fantasy Nerd's look at the best and worst matchups for Week 15 of the 2025 NFL season. Analysis is aggregated from multiple sources including FN. Rankings are based upon PPR (point per reception) scoring. Given the known conditions, these matchups are the ones to watch and/or avoid.
Please Note: This list does not generally include the elite players that you are going to start regardless of matchup. You don't need us to tell you to start Josh Allen, Puka Nacua, or Christian McCaffrey. Instead, we take a look at other players on your team that we believe either have great matchups or should be avoided for multiple reasons. Factors like opposing defense, performance trending, and peer comparisons may influence our decisions.

Start 'em Jaxson Dart (NYG, QB)Jaxson Dart, who returned from a concussion in Week 13, draws a favorable Week 15 matchup against Washington, which allows 382.5 scrimmage yards per game (30th), has given up 26 passing touchdowns (T-28) and 13 rushing scores (T-18). In his comeback he totaled 139 passing and 20 rushing yards for a quiet 15.6 fantasy points - his worst output since becoming the starter - but the Commanders have been vulnerable to quarterbacks (they rank near the bottom in fantasy points allowed, and six of the last eight opposing QBs have posted at least 21.9 fantasy points, including J.J. McCarthy). Given the matchup, Dart should rebound and can be viewed as a top-10 fantasy quarterback option.


Start 'em Baker Mayfield (TB, QB)Baker Mayfield will look to shake off a recent slump and record his first multi-touchdown game since Week 10 when the Buccaneers face the Falcons in Week 15. He's managed just one TD and under 200 passing yards in each of his last four games, with only one multi-TD performance since Week 6, but Tampa Bay still tops the NFC South and needs a reboot through the air. Atlanta has been exploitable lately (Sam Darnold threw for 249 yards and three TDs last Sunday) and ranks about average in fantasy points allowed to quarterbacks, and Mayfield has historically thrived against the Falcons - scoring 24+ fantasy points in each of his last four meetings. With Mike Evans and Jalen McMillan potentially back to restore the full receiving corps, Week 15 looks like a good spot for a bounce-back.


Start 'em TreVeyon Henderson (NE, RB)Heading into Week 15 against Buffalo, TreVeyon Henderson looks to be in a timeshare with Rhamondre Stevenson after logging just a 49% snap share and 14 touches (both five-game lows) before the bye. The matchup is appealing - the Bills are surrendering about 5.0 yards per carry and 25.3 PPR points per game to running backs - but Henderson remains a boom-or-bust piece who offers home-run upside more than short-yardage opportunity, making him better suited as a flex or low-end RB2. He has topped 11.1 PPR and reached at least 14 touches in both games since Stevenson returned, while Stevenson himself still commands meaningful work and looks like a viable flex option as well.


Start 'em Woody Marks (HOU, RB)Woody Marks logged a career-high 28 touches in Houston's Week 14 win (26 carries, two catches) - finishing with 68 rushing yards, 8 receiving yards and a touchdown - and with Nick Chubb exiting that game with a rib issue he's become the Texans' lead back. He now faces a Cardinals defense that has allowed 18 rushing TDs to running backs and ranks among the more generous units for opposing RBs, so Marks should again see a heavy workload. His 3.5 yards per carry is disappointing, but his every-down role and the matchup make him a solid RB2 for Week 15 if Chubb remains limited.


Start 'em Wan'Dale Robinson (NYG, WR)Wan'Dale Robinson has emerged as the Giants' primary receiving option, posting at least eight targets in five straight games and ranking 10th in the NFL in receptions while averaging 5.6 catches and 8.5 targets per contest. He draws a favorable Week 15 matchup against the Commanders, who allow 246.9 passing yards per game (30th), have given up 26 passing touchdowns (tied for 28th) and sit among the league's worst defenses versus fantasy wideouts. With 53 targets over his last five games, three outings of at least 12.2 PPR points and a Week 1 line of six catches for 55 yards on eight targets vs. Washington, Robinson is a solid No. 2 fantasy option - and Darius Slayton is a reasonable sleeper now that Jaxson Dart is under center.


Start 'em Terry McLaurin (WAS, WR)Terry McLaurin did little last week - three catches for 41 yards on six targets in a 31-0 loss - but he draws a much easier Week 15 assignment. The Giants have been one of the league's weaker pass defenses, giving up more than 230 passing yards per game and regularly producing big fantasy outings for opposing receivers (multiple wideouts have topped 12.9 PPR and at least one has scored in every game). With Marcus Mariota expected to start again - and McLaurin having posted at least 14.4 PPR in both of his prior starts with Mariota - McLaurin projects as a solid No. 2 fantasy option, while Deebo Samuel remains usable as a No. 3 after his 22.6 PPR in Week 1.


Start 'em Harold Fannin (CLE, TE)Harold Fannin has become Shedeur Sanders' primary option in Cleveland, logging at least five targets in eight straight games. He turned in a 114-yard, one-touchdown outing on eight catches in Week 14 as the Browns leaned on the pass - a trend that could continue in a potentially high-scoring Week 15 at Chicago. Fannin has scored in two of Sanders' three starts, posted a career-best 25.4 fantasy points last week, and could see even more volume if David Njoku (knee) is unavailable. With the Bears allowing nearly 14 PPG to opposing tight ends over the last eight weeks, he's a viable mid-tier streaming play.


Start 'em Mark Andrews (BAL, TE)Andrews, who recently signed a contract extension, has been targeted at least five times in four of his last five games but has managed just one touchdown and only once topped 35 receiving yards in that span. Isaiah Likely's increased involvement over the past two weeks makes Andrews a shaky fantasy option for Week 15, though the matchup offers hope - Cincinnati has been the league's worst unit against tight ends, frequently allowing big fantasy totals and 12+ PPR games to the position. After a 1âforâ9, 1.9âpoint outing in Week 14, Andrews is more of a desperation streamer, but both he and Likely are playable given how poorly the Bengals defend TEs.


Start 'em Philadelphia Eagles (PHI, DEF)The Eagles' defense is a prime streaming target this week at home against Las Vegas. The Raiders' offense has been a wreck - ranking last in points and total net yards per game over the past eight weeks and surrendering a league-high 32 sacks in that span - so expect Philadelphia to control what should be a one-sided game.


Start 'em Cam Little (JAC, K)Since Jacksonville's Week 8 bye, Cam Little is a perfect 11-for-11 on field goals and 19-for-19 on extra points while the Jaguars have put up at least 25 points in every game. With plenty of range and scoring chances expected in Week 15 at home against a Jets defense that allows 26.8 points per game - and one that has yet to hold a kicker under seven fantasy points (eight kickers have reached nine or more) - Little is a strong fantasy start after posting 11+ points in four of his last six games, including 11 last week vs. the Colts.


Sit 'em Caleb Williams (CHI, QB)Caleb Williams went 19-for-35 for 186 yards, two TDs and an INT in the Bears' Week 14 loss, but despite steering Chicago toward a playoff spot his fantasy output has been modest - he's thrown for 200 yards or fewer in three of his last four starts and scored under 20 fantasy points in three of those games (18.9 in Week 14). That struggles are likely to persist in Week 15, when he draws a Browns defense that ranks among the league's best against the pass (185.5 yards allowed per game), pressures quarterbacks consistently, and is stingy in fantasy scoring allowed. With Rome Odunze (foot) a question mark and Chicago leaning on the run, Williams is a viable start only in Superflex or two-QB formats.


Sit 'em Bo Nix (DEN, QB)Despite limited production - just three touchdowns in his last four starts (two passing, one rushing) and no multi-TD game since Week 9 - Bo Nix has guided Denver to a 10-game winning streak while completing 67.6% of his passes as the defense carries much of the load. He's scored 18.4 fantasy points or fewer in each of his past four games and now draws a tough Week 15 matchup against a Green Bay unit that ranks among the league's stingiest versus quarterbacks, often holding QBs under 19 fantasy points. Nix is therefore a risky option in one-QB leagues and is best left to Superflex or two-QB formats.


Sit 'em Tony Pollard (TEN, RB)Tony Pollard erupted for 161 rushing yards and two touchdowns on 25 carries in Week 14 at Cleveland, finishing with a season-high 28.1 PPR despite catching no passes. That outburst snapped a long stretch of modest production - no TDs since Week 5 and five straight games of 8.1 PPR or fewer - and he still shares work with Tyjae Spears, who handles most passing-down looks. Now he draws a tough San Francisco run defense allowing just 86 rushing yards per game and few RB touchdowns, increasing the risk Tennessee falls behind and leans pass-first. Pollard is back in RB2 conversation, but given the matchup and his inconsistency, he's more of a risky flex than a reliable starter.


Sit 'em Xavier Worthy (KC, WR)Xavier Worthy has been a modest, steady target in Kansas City's offense but offers limited upside. Over the last seven games he hasn't found the end zone, tallying a 25-311-0 line on 41 targets while catching at least three passes each week, and he hasn't reached double-digit targets in any 2025 game. Facing a Chargers secondary that ranks second-fewest in PPR points allowed to receivers in Week 15, the Chiefs' No. 2 wideout looks like a risky fantasy play - even in three-WR formats - especially with Patrick Mahomes dealing with an injured offensive line. Rashee Rice presents the more appealing option for the fantasy playoffs.


Sit 'em Zay Flowers (BAL, WR)Zay Flowers has been a dependable floor play most of the year but flashed rare upside in Week 14, ripping off three receptions of 30+ yards and finishing with a team-high eight catches on 11 targets for 124 yards - his first 100-yard game since Week 1 - while clearly syncing with Lamar Jackson. He draws a tough Week 15 rematch with Cincinnati, who've been stingy to opposing receivers lately (fewest fantasy points allowed over the last five weeks and no WR in the past four games has reached double-digit PPR), and he was limited to two catches for six yards the last time they met. That makes Flowers a solid FLEX/WR3 with WR2 upside in a high-scoring forecast, but he's best started mainly in three-receiver or deeper formats.


Sit 'em Kareem Hunt (KC, RB)Kareem Hunt found the end zone in Week 14, his sixth touchdown in as many games, but he's produced just 399 scrimmage yards in that span (only once topping 80) at 3.8 yards per carry. Isiah Pacheco's return hasn't meaningfully reduced Hunt's role - Hunt has eight rushing TDs on the season, one shy of his career high, and has been the Chiefs' primary back - but his volume is limited: Week 14 was 12 carries for 30 yards, one target and 9.0 PPR points. He'll try to keep the streak alive in Week 15 against a Chargers run defense that's been middling overall and has allowed only four RB rushing TDs since Week 7; they also held Kansas City's backs out of the end zone in Week 1 when Hunt and Pacheco combined for just 41 rushing yards and 13 receiving yards. I'd still consider Hunt a flex play because of his recent touchdown frequency (five of six games), but Kansas City's O-line issues mean he'll be of limited fantasy value unless he finds the end zone.


Sit 'em Hunter Henry (NE, TE)After two strong outings (11 catches for 188 yards and a TD) before the Week 14 bye, Hunter Henry still faces a tough test in Week 15: those performances came against weaker tight-end defenses, while Buffalo has allowed the fewest fantasy points to TEs all year (just 7.2 PPR per game). Henry has topped four catches seven times and remains one of New England's primary targets, but he was limited to two catches and 6.6 fantasy points in his first meeting with the Bills. Mike Gesicki's 20.6-point week was a rare exception - only one other tight end has cleared 7.5 points against Buffalo this season - so I'd leave the veteran on the bench for this AFC East clash.


Sit 'em Dallas Goedert (PHI, TE)After a quiet stretch, Dallas Goedert flashed again in the OT loss to the Chargers with 8 catches on 10 targets for 78 yards - his second-highest yardage and second-most targets of 2025 - but that may not be enough to trust him moving forward. The Raiders present a mixed passing profile (allowing 211.8 yards per game, 17th) yet have been tough on tight ends, ranking fourth against the position and giving up just one TE touchdown and the fewest TE fantasy points in the last eight weeks. With Goedert having posted single-digit outputs in five of his last six games despite a strong start to the season, keep him on the bench for Week 15.


Sit 'em New England Patriots (NE, DEF)On paper this looks manageable - Buffalo has allowed 11 sacks and been flagged for 11 turnovers in the past four weeks - but backing any defense against a Josh Allen-led attack is risky. The Bills are averaging about 30 points and more than 380 total yards per game, so New England's defense should be treated with caution in this crucial AFC East showdown at Foxboro.


Sit 'em Harrison Butker (KC, K)Butker missed his first field goal since Week 4 in Kansas City's Week 14 loss to the Texans, emblematic of a so-so season. His 84.6% field-goal rate is similar to last year, but an 87.9% mark on extra points would be a career low, and he sits 15th in scoring among kickers. The Chiefs have only given him more than two field-goal attempts once in the past nine games, and he's posted single-digit fantasy scores in all but one of those contests (just three last week), so his upside is limited. Facing a Chargers unit tied for ninth in points allowed - and one that has yielded under seven fantasy points to kickers since Week 7 - Butker looks like a fade in Week 15, despite going 22-for-26 on FGs and 28-of-32 on XPs this year and having scored 11 in Week 1.

