This is the Fantasy Nerd's look at the best and worst matchups for Week 10 of the 2025 NFL season. Analysis is aggregated from multiple sources including FN. Rankings are based upon PPR (point per reception) scoring. Given the known conditions, these matchups are the ones to watch and/or avoid.
Please Note: This list does not generally include the elite players that you are going to start regardless of matchup. You don't need us to tell you to start Lamar Jackson, Justin Jefferson, or Christian McCaffrey. Instead, we take a look at other players on your team that we believe either have great matchups or should be avoided for multiple reasons. Factors like opposing defense, performance trending, and peer comparisons may influence our decisions.
Start 'em Caleb Williams (CHI, QB)Caleb Williams turned in one of his most complete outings in Week 9 and draws a favorable Week 10 matchup against a Giants defense that allows the seventh-most fantasy points to quarterbacks (23.4 per game). After piling up 44.7 fantasy points in Cincinnati, he has a good shot to stay hot - New York has given up at least 22.6 fantasy points to opposing QBs in three of the last four games, and Williams has posted 26.2-plus fantasy points in two of his three games in Chicago this season.
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6th Most Pts to QB
Start 'em Jaxson Dart (NYG, QB)Jaxson Dart added three total touchdowns in Week 9 and continues to deliver fantasy upside even without gaudy passing numbers, making him a tempting Week 10 start against a Bears unit that's been one of the league's worst to quarterbacks (29th in QB defense, fifth-most fantasy points allowed). In six starts he's been remarkably steady - at least 21.4 fantasy points in five of them (his low: 19.6 in Week 5 at New Orleans) - and has produced either 55 rushing yards or a rushing TD every start, including a four-game touchdown streak. Malik Nabers (knee) won't be available, but Dart is creating plays with Wan'Dale Robinson, Darius Slayton and Theo Johnson, giving him strong top-five upside in many leagues and a bright future.
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4th Most Pts to QB
Start 'em Quinshon Judkins (CLE, RB)If Judkins is cleared to play Week 10, he'll have a favorable matchup against the Jets, who have allowed about 21.4 PPR points per game to running backs (25th overall) and were already yielding plenty of RB fantasy production before trading Quinnen Williams to Dallas. Expected to return after the Week 8 shoulder injury and Cleveland's bye, Judkins had at least 13.8 PPR in four of five games prior to the injury, making him a borderline No. 1 option in all formats if he's healthy - and potentially one of his best games of the year.
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10th Most Pts to RB
Start 'em Kyle Monangai (CHI, RB)Kyle Monangai erupted for a new career high of 198 total yards (26 carries for 176 yards and three catches for 22) in Week 9, and with D'Andre Swift (groin) uncertain for Week 10, he could do serious damage against a Giants run defense allowing a league‑high 5.9 yards per carry. Even if Swift suits up, Monangai makes a workable low‑end start; without Swift he carries clear top‑five upside after posting double‑digit carries and at least 17.4 PPR points in two games this year. New York ranks second in fantasy points allowed to RBs, and recent backfields have piled up heavy rushing and receiving production, so Monangai has a real chance for another big performance.
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2nd Most Pts to RB
Start 'em Romeo Doubs (GB, WR)With Tucker Kraft sidelined (ACL) and Matthew Golden limited by a shoulder issue, Romeo Doubs should see a larger share of targets in Week 10, though Green Bay may still favor the run against an Eagles defense that is yielding just 7.5 yards per target to wideouts. Doubs has been a frequent focal point recently - eight or more targets in four of his last five games and at least 13.2 PPR points in three of those outings, including a 7-catch, 91-yard performance on 10 targets last week when Kraft was hurt. Ten receivers have seen seven or more targets against Philadelphia this year, and eight of them produced at least 12.9 PPR points. I view Doubs as a solid No. 2 fantasy receiver in most leagues.
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13th Fewest Pts to WR
Start 'em Quentin Johnston (LAC, WR)Quentin Johnston looks to be trending upward even as he battles Keenan Allen for the Chargers' WR2 role, and he could be primed for a strong Week 10 against a weak Steelers secondary. After a zero-target outing in Week 8, he rebounded in Tennessee with four catches for 53 yards and a touchdown on five targets. Pittsburgh is the league-worst defense in fantasy points allowed to receivers - 10 different pass-catchers have topped 15.4 PPR against them this year (three just last week) - and with Ladd McConkey, Johnston and Allen all set to benefit, Johnston should see chances to make downfield plays.
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Most pts to WR
Start 'em Colston Loveland (CHI, TE)If Cole Kmet misses Week 10 with a concussion, Colston Loveland could step into Chicago's primary tight end role against the Giants - a defense that yields just 5.9 yards per target to TEs but has still allowed four games of at least 11.6 PPR points to the position this season (two in the last four weeks). After a breakout at Cincinnati - six catches for 118 yards and two TDs on seven targets - Loveland is a sensible low-end start in all formats. Keep an eye on Kmet; if he's out, Loveland's involvement from Caleb Williams and play-caller Ben Johnson should increase.
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13th Fewest Pts to TE
Start 'em Dalton Schultz (HOU, TE)Dalton Schultz has been a steady option of late - he's recorded at least five catches in five of his past six games and reached double-digit PPR in three of his last four. He piled up six receptions for 77 yards on eight targets in Week 9 and earlier caught five passes for 39 yards at Jacksonville in Week 3. With C.J. Stroud sidelined by a concussion this week, Schultz should still see enough work against a Jaguars defense that's been surprisingly generous to tight ends (a TE has scored at least 10.1 PPR in each of the last five games and Jacksonville ranks second in fantasy points allowed to the position).
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2nd Most Pts to TE
Start 'em Cleveland Browns (CLE, DEF)After piling up 10 sacks in the last two meetings with Tua Tagovailoa and forcing four interceptions and two fumble recoveries, the Browns' defense heads into the bye hot. The Jets have allowed at least four sacks in five games and have scored 11 points or fewer twice in their last three, so I'm siding with the Browns as my top DST for Week 10.
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9th Most Pts to DEF
Start 'em Jason Myers (SEA, K)Jason Myers has missed just four kicks all season and should be active again in Week 10 when Seattle faces Arizona, as the Seahawks consistently generate kicking chances. In their first meeting he went 3-for-4 on field goals - including a 50+ yarder - and 2-for-2 on extra points, making him one of only three kickers with at least three FGs against the Cardinals this year. I expect him to be a top-five fantasy kicker in all formats.
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12th Most Pts to K
Sit 'em Trevor Lawrence (JAC, QB)Trevor Lawrence heads into Week 10 with a 9:6 TD‑to‑INT mark and faces a Texans defense that has allowed just eight passing TDs all season. Brian Thomas Jr. is questionable with an ankle issue, and although Jakobi Meyers helps offset Travis Hunter's absence, Houston is the stingiest unit against opposing QBs in fantasy. Lawrence has posted at least 19.6 fantasy points in four straight games, but against the Texans over their last five meetings he's averaged about 215 passing yards with five total TDs and four INTs. He's primarily a start in Superflex or two‑QB formats, not in one‑QB leagues.
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Feweset Pts to QB
Sit 'em Aaron Rodgers (PIT, QB)Aaron Rodgers threw for 203 yards, one TD and no interceptions in Pittsburgh's Week 9 win, but he'll face a stiff road test in Week 10 against the Chargers, who allow just 14.5 fantasy points per game to QBs (fourth fewest). Rodgers managed only 14.1 fantasy points last week as the Steelers leaned on five turnovers and two Jaylen Warren rushing TDs to win. With only Patrick Mahomes, Jaxson Dart and Daniel Jones topping 20 fantasy points vs. L.A. this year, Rodgers is best considered mainly in Superflex and two‑QB formats.
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3rd Fewest Pts to QB
Sit 'em Tyrone Tracy (NYG, RB)Tyrone Tracy saw a limited Week 9 role - just five carries for 18 rushing yards (eight touches for 37 total) - while Devin Singletary out-produced him with 10 touches for 51 yards and more snaps (32–25). Facing a Bears defense that ranks 22nd versus fantasy running backs, Tracy looks like a timeshare option at best; if the coaching staff favors Singletary, I'd plug Singletary into lineups over Tracy for Week 10.
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12th Most Pts to RB
Sit 'em Alvin Kamara (NO, RB)Alvin Kamara has found the end zone just once this season and in Week 10 draws a Carolina run defense that grades out as roughly league‑average against backs. He struggled in Week 9 at the Rams (six carries for 14 yards, one catch for 3 yards on three targets, plus a lost fumble) and has posted 6.5 PPR points or fewer in each of the last three games, with no touchdown since Week 1. Carolina has allowed 53.6 PPR points to James Cook and Josh Jacobs over the past two weeks, so Kamara has some flex appeal on paper, but his inconsistency keeps him from being a reliable must‑start in most leagues.
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14th Most Pts to RB
Sit 'em Deebo Samuel (WAS, WR)Deebo Samuel has been underwhelming lately, but with Terry McLaurin (quadriceps) expected to remain out, Samuel should see a large role in Week 10 against a Lions defense that ranks 27th versus fantasy wide receivers - even with Marcus Mariota taking over at quarterback. He enters the game in a three-game funk (12 catches for 67 yards, zero TDs on 17 targets across those matchups) and has posted 9.4 PPR points or fewer each time. Samuel has also struggled with Mariota under center before, recording 4.9 PPR or less in two of three starts together this season, so he's only a start in deeper, three-wide formats this week.
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10th Most Pts to WR
Sit 'em Tre Tucker (LV, WR)Since his three-TD outburst in Week 3, Tucker has averaged just 3.8 catches for 43.2 yards with no scores, so he's unlikely to move the needle in Week 10. He's now the Raiders' top receiver after Jakobi Meyers was traded, but Denver - which gives up the fewest fantasy points to WRs and has allowed only two receiving TDs all season - remains a tough matchup even if Patrick Surtain II (pectoral) sits. I like Tucker's upside down the stretch with Meyers gone, but I wouldn't trust him as a start in most leagues this week.
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2nd Fewest Pts to WR
Sit 'em T.J. Hockenson (MIN, TE)T.J. Hockenson has been targeted only three times in each of Minnesota's last two games, and with rookie QB J.J. McCarthy still settling in, his ceiling is limited - especially versus a Baltimore defense that allows just about 7.6 fantasy points to tight ends per game. Despite a Week 9 touchdown, he had only two catches for 11 yards on three targets and is averaging roughly 5.3 PPR points in his three starts with McCarthy; the Ravens have given up just two TE scores all year. That makes Hockenson a Week 10 option only in deeper leagues.
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15th Most Pts to TE
Sit 'em Hunter Henry (NE, TE)Hunter Henry should be one of New England's primary receiving options in Week 10 against a Buccaneers defense that has allowed 13.4 PPR points per game to tight ends. He finished Week 9 with four catches for 51 yards on six targets, but has been limited recently - 9.1 PPR points or fewer in five straight games and no more than 7.3 points in any of his four road appearances. With Tampa Bay not allowing a tight end touchdown since Week 5 (including games against Sam LaPorta and Juwan Johnson), Henry is only a viable start in deeper leagues this week.
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15th Fewest Pts to TE
Sit 'em Green Bay Packers (GB, DEF)After a lackluster Week 9 showing against Carolina - just one sack, one interception and 16 points allowed - Green Bay's defense, which also gave up 23-plus in games against Arizona and Pittsburgh, draws a tough matchup with Philadelphia. The Eagles have scored at least 28 points in four of their last six and have only three turnovers all season, so I'd steer clear of the Packers DST in most Week 10 leagues.
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11th Fewest Pts to DEF
Sit 'em Cam Little (JAC, K)Cam Little's Week 9 outing in Las Vegas was spectacular - a perfect day with three field goals, including an NFL-record 68-yarder, and two PATs - but it followed a stretch in which he missed kicks in four of six games and hadn't hit a field goal since Week 5. That volatility could limit his chances in Week 10 against Houston, a unit allowing just 15.1 points per game and the fewest fantasy points to kickers; Little went 1-for-2 on FGs when he faced the Texans in Week 3, and only one kicker has knocked down multiple field goals against them this year.
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Feweset Pts to K
