This is the Fantasy Nerd's look at the best and worst matchups for Week 4 of the 2025 NFL season. Analysis is aggregated from multiple sources including FN. Rankings are based upon PPR (point per reception) scoring. Given the known conditions, these matchups are the ones to watch and/or avoid.
Please Note: This list does not generally include the elite players that you are going to start regardless of matchup. You don't need us to tell you to start Lamar Jackson, Saquon Barkley, or Puka Nacua. Instead, we take a look at other players on your team that we believe either have great matchups or should be avoided for multiple reasons. Factors like opposing defense, performance trending, and peer comparisons may influence our decisions.

Start 'em Geno Smith (LV, QB)After a mixed start with the Raiders, Geno Smith produced his best game in Week 3 - 289 yards and three TDs with no interceptions - and is currently averaging a career-pace 7.8 yards per attempt. His reunion with Pete Carroll has looked positive despite a 1–2 record, and the offense should improve as Brock Bowers manages a minor knee issue and rookie Ashton Jeanty seeks a breakout. Facing an injury-depleted Bears defense that has allowed the most passing touchdowns and abundant fantasy production to opposing quarterbacks and running backs, Smith projects as a top-10 fantasy QB and a strong candidate for another big outing in what could be a shootout with Caleb Williams.


Start 'em Caleb Williams (CHI, QB)Caleb Williams and the Bears head to Las Vegas off a 31-14 Week 3 win over Dallas in which he went 19-of-28 for 298 yards, four touchdowns and added 12 rushing yards - easily the best game of his young career. He handled Dallas' aggressive front well, spreading the ball to multiple targets and protecting it under pressure, and he's clearly settling into Ben Johnson's offense with plenty of weapons around him. The Raiders are more balanced than the Cowboys but remain vulnerable through the air (allowing 7.8 yards per pass attempt) and have surrendered big fantasy outings to recent opposing QBs, so Williams carries solid QB1/top-five upside after posting at least 20.9 fantasy points in each game this season.


Start 'em Omarion Hampton (LAC, RB)Omarion Hampton will assume the Chargers' lead-back role after Najee Harris suffered a season-ending Achilles tear in Week 3. He flashed upside stepping in versus Denver - 19 carries for 70 yards and a rushing TD plus six catches for 59 yards (129 scrimmage yards) - and appears to fit Greg Roman's scheme with little competition from Hassan Haskins or Kimani Vidal. Facing a Giants run defense that has struggled and ranks near the bottom in fantasy points allowed to backs, Hampton has a prime Week 4 opportunity and looks like a borderline RB1 in most formats.


Start 'em Trey Benson (ARI, RB)With James Conner sidelined for the season by a foot/ankle injury, Trey Benson will step into the Cardinals' lead-back role for Week 4 against Seattle. Benson has shown explosiveness in limited work - 21 carries for a 6.0-yard average through three weeks - and should see the bulk of the touches, though the Seahawks have been tough against the run (about 3.16 yards per carry allowed). Given the expanded role and his efficiency, Benson is a viable No. 2 fantasy option for Thursday night despite the challenging matchup.


Start 'em Deebo Samuel (WAS, WR)Deebo Samuel was unusually quiet in Week 3 - just 29 yards on five touches - despite Washington's 41-point win. The Jayden Daniels-to-Marcus Mariota switch and Terry McLaurin's quadriceps issue (he's unlikely for Week 4) help explain the limited role; if McLaurin sits, Samuel should see a much bigger target share. Still, Atlanta is stingy against the pass (about 131 yards allowed per game, best in the NFL) and a top-10 fantasy matchup for receivers, even with A.J. Terrell out with a hamstring injury. Samuel has two games of at least 17.4 PPR points this season and projects as a solid No. 2 fantasy option.


Start 'em Keenan Allen (LAC, WR)Keenan Allen has looked revitalized in his return to the Chargers, scoring a touchdown in each of the first three games while posting at least five catches and 60 yards per outing (19-194-3 on the season) and leading the team with 28 targets from Justin Herbert. Quentin Johnston (14-239-3 on 24 targets) and Ladd McConkey (15-163 on 21 targets) are close behind, and any of the trio could explode in a given week. With the Giants' secondary ranking near the bottom in catches and receiving yards allowed to wideouts - and one of the league's worst marks in fantasy points surrendered to receivers - Allen has clear flex upside and all three Chargers are viable Week 4 starts.


Start 'em Hunter Henry (NE, TE)Hunter Henry looks like New England's most reliable receiving weapon heading into a favorable Week 4 matchup with the Panthers. Fresh off an 8-catch, 90-yard, 2-TD outing on 11 targets and totaling 22 looks through three games, he's built some momentum despite a spotty career track record. Carolina has been vulnerable to tight ends - allowing the fifth-most fantasy points to the position, 18 catches for 222 yards and a score through three weeks, with five different TEs posting at least 6.5 PPR (Trey McBride had 13.8 in Week 2) - so Henry profiles as a confident TE1 and a top-10 fantasy option this week.


Dalton Kincaid has been a steady presence at tight end for the Bills and brings real scoring upside into Week 4 against the Saints. He's caught at least four passes in each game so far and already has two touchdowns, with 12 targets across his last two outings, and two 14.8+ PPR performances this season. While Buffalo's likely game script could limit opportunities and New Orleans hasn't allowed many chunk plays to opposing tight ends, the Saints have still given up a fair number of TE receptions overall - and Kincaid is healthy and likely to remain one of Josh Allen's top targets. For Week 4, he's a clear No. 1 fantasy tight end option.


Start 'em Detroit Lions (DET, DEF)Cleveland has been limited to 17 points or fewer in each of its three games, has allowed six sacks, and has turned the ball over via four interceptions and a fumble; Detroit's defense and special teams should be able to keep the Browns' offense under control in this matchup.


Start 'em Matt Prater (BUF, K)Distance limits Matt Prater's upside in Week 4, but his consistency gives him a reliable floor. He's missed just one field goal this year and has converted most PATs, and with Buffalo likely to lead early against a Saints defense that allows roughly 10 fantasy points to kickers (third-most in the league), he should see plenty of chances. After the Week 3 miss he still scored, and his steady production makes him a safe, top-10 fantasy kicker start.


Sit 'em Dak Prescott (DAL, QB)Despite consecutive games of 250+ passing yards and a touchdown, Dak Prescott heads into Week 4 with a shaky outlook after losing his top target CeeDee Lamb to an ankle injury - Lamb exited last game after just over a quarter and is unlikely to play. George Pickens and Jake Ferguson can help fill the void, but the Cowboys' passing game is hampered against a Packers secondary that allows just 168 passing yards per game (seventh-best) and ranks among the stingiest in fantasy points allowed to quarterbacks (second fewest). Prescott tossed two interceptions in the Week 3 loss, has been under 15 fantasy points in two of three games, and faces added offensive-line worries with Tyler Booker and Cooper Beebe out, even as Micah Parsons returns. Given the matchup and injuries, he's a risky start - especially in Superflex and two-QB leagues.


Sit 'em Kyler Murray (ARI, QB)Coming off a tough loss to San Francisco, Kyler Murray heads into Week 4 against Seattle after completing 22-of-35 throws for 159 yards and a touchdown while adding 37 rushing yards on six carries. He again targeted Trey McBride heavily (eight targets, five catches, 43 yards, TD), but faces a Seahawks defense that's second in the league with five interceptions, has allowed just four passing TDs, and ranks among the stingiest against opposing quarterbacks in fantasy. Murray has failed to eclipse 165 passing yards in two of three games and has scored 16.1 fantasy points or fewer in his last two outings, making him a risky start best limited to Superflex or two-QB formats.


Sit 'em D'Andre Swift (CHI, RB)D'Andre Swift heads to Las Vegas in Week 4 hoping for more efficiency after a Week 3 win over Dallas in which he posted a season-high 78 total yards (13 rushes for 33 yards, three catches for 45 yards). His receiving work continues to be his fantasy floor, keeping him in RB2/flex consideration - especially in PPR - despite facing a Raiders front that has been tough on early-down runs and is allowing roughly 4.6 yards per carry to opposing backs. Snap share remains a concern (Swift played about 61% while a teammate saw near 30%), so with his role not firmly cemented he's best used as a flex in most formats for Week 4.


Sit 'em Isiah Pacheco (KC, RB)Isiah Pacheco managed just 45 yards on 10 carries in Week 3 and remains without a touchdown in 2025, losing a redâzone score to Kareem Hunt as the Chiefs' backfield continues to be a timeshare. His season average (3.7 yards per carry) lags behind his early-career marks, though he did average 4.5 YPC in Week 3; that limited role and the offense's inconsistency keep his ceiling low. Still, a Week 4 matchup with a Ravens run defense that's been exposed could give him flex appeal, but I'd lean toward starting Hunt - and view both backs as only flex-worthy in deeper formats.


Sit 'em Jerry Jeudy (CLE, WR)Jerry Jeudy remains a regular target for Cleveland - he's seen at least five targets in each game - but he hasn't scored and hasn't reached 70 yards in any outing. That limited production makes him a risky play for Week 4 at Detroit (a defense that's been beatable at times but recently shut down Lamar Jackson and the Ravens), leaving Jeudy as a low-upside WR3/FLEX. He managed just one catch on five targets for 17 yards in Week 3, and with Joe Flacco spreading the ball, similar modest output is likely; through three games Jeudy has 10 catches for 134 yards on 21 targets, no touchdowns, and has scored 11.6 PPR points or fewer in each contest. Cedric Tillman has been Cleveland's better Fantasy option, and Jeudy isn't a recommended start in most leagues this week.


Sit 'em Jameson Williams (DET, WR)Coming off a 38-30 win over Baltimore, Jameson Williams and the Lions head to Cleveland in Week 4, and he remains a boom-or-bust option. Through three games he's flashed big-play ability - including a 44-yard TD and a 18.8 PPR outing in Week 2 - but his target volume is low (12 on the season, about four per game), which limits his floor. Facing a strong Browns secondary that typically shuts down opposing receivers, Williams' ceiling here depends on one of those long gains; he's a borderline start best reserved for deeper, three-receiver formats.


Sit 'em Harold Fannin (CLE, TE)Harold Fannin remains an integral part of the Browns' offense, playing over 60% of snaps, but his target volume has dipped for three straight weeks as David Njoku and emerging receiver Isaiah Bond siphon looks. The rookie caught three of four targets for 25 yards in Week 3, yet his production has trended down since a 13.6 PPR outing in Week 1 (just 5.5 PPR in Week 3). With Detroit having surrendered multiple tight end touchdowns and ranking poorly against the position, Week 4 could offer a bounce-back chance - making Fannin a sensible deep-league streaming option and a low-end starter in many formats; Njoku is worth similar consideration.


Sit 'em Mark Andrews (BAL, TE)After a slow start, Andrews re-emerged with six catches for 91 yards and two TDs in Week 3, but he's still a risky option - only 10 targets through three games - and Isaiah Likely's possible return plus a difficult Week 4 matchup against Kansas City's stingy unit (allowing just 4.8 fantasy points to TEs) leave him a borderline TE1. If you have alternatives, it's safer to look elsewhere.


Sit 'em Atlanta Falcons (ATL, DEF)The Falcons DST looked like a fade after Week 3 - Atlanta's offense was chaotic in a 30-0 loss to Carolina and the defense managed only one sack. Even with Jayden Daniels (knee) sidelined, I wouldn't trust this unit against Washington, who just put up 41 points with Marcus Mariota, so the Falcons DST should remain on most waiver wires for Week 4.


Sit 'em Cam Little (JAC, K)Cam Little, in his second season out of Arkansas, is 7-for-8 on field-goal attempts and a perfect 7-for-7 on extra points through three games; although he hasn't tried a regular-season kick beyond 50 yards, he demonstrated the leg with a 70-yarder in the preseason. Facing a San Francisco defense that has allowed the fifth-fewest points and kept opposing kickers (Jason Myers, Blake Grupe and Chad Ryland) under eight fantasy points this year, Little's upside is limited - after a Week 3 miss that yielded just five fantasy points, he's only a viable start in deeper leagues for Week 4 on the road.

