Players have had the opportunity to opt out of the 2020 season due to the COVID-19 pandemic. The player simply had to provide the team with a written notice indicating their choice no later than 4:00 pm ET today. A player may still opt out later under certain conditions, but as of right now, the following players are not expected to play in the 2020 NFL season.
| Arizona Cardinals | OL Marcus Gilbert |
| Baltimore Ravens | KR De'Anthony Thomas OL Andre Smith |
| Buffalo Bills | DT Star Lotulelei CB E.J. Gaines |
| Carolina Panthers | LB Christian Miller LB Jordan Mack |
| Chicago Bears | DT Eddie Goldman S Jordan Lucas |
| Cincinnati Bengals | DT Josh Tupou OT Isaiah Prince |
| Cleveland Browns | OL Colby Gossett G Drew Forbes T Drake Dorbeck DT Andrew Billings G Malcolm Pridgeon |
| Dallas Cowboys | CB Maurice Canady WR Stephen Guidry FB Jamize Olawale |
| Denver Broncos | DT Kyle Peko RT Ja'Wuan James |
| Detroit Lions | DT John Atkins WR Geronimo Allison C Russell Bodine |
| Green Bay Packers | WR Devin Funchess |
| Houston Texans | DT Eddie Vanderdoes |
| Indianapolis Colts | LB Skai Moore DB Rolan Milligan DB Marvell Tell |
| Jacksonville Jaguars | EDGE Lerentee McCray CB Rashaan Melvin DT Al Woods |
| Kansas City Chiefs | RB Damien Williams OT Lucas Niang OL Laurent Duvernay-Tardif |
| Las Vegas Raiders | DB D.J. Killings DE Jeremiah Valoaga LB Ukeme Eligwe |
| Los Angeles Rams | OT Chandler Brewer |
| Miami Dolphins | WR Allen Hurns WR Albert Wilson |
| Minnesota Vikings | DT Michael Pierce |
| New England Patriots | S Patrick Chung TE Matt LaCosse LB Dont'a Hightower FB Dan Vitale RB Brandon Bolden OL Najee Toran WR Marqise Lee OL Marcus Cannon |
| New Orleans Saints | TE Jason Vander Laan TE Cole Wick |
| New York Giants | OL Nate Solder WR Da'Mari Scott CB Sam Beal |
| New York Jets | OL Leo Koloamatangi LB C.J. Mosley WR Josh Doctson |
| Philadelphia Eagles | WR Marquise Goodwin |
| San Francisco 49ers | WR Travis Benjamin OL Shon Coleman |
| Seattle Seahawks | OL Chance Warmack |
| Tampa Bay Buccaneers | OT Brad Seaton |
| Tennessee Titans | OL Anthony McKinney |
| Washington Football Team | DE Caleb Brantley LB Josh Harvey-Clemons |
