Isaac Guerendo

Isaac Guerendo

RB - SF
Height:
Weight: lbs
Age: --
College: Louisville
San Francisco 49ers

2025 Season Outlooks

Maybe you took Christian McCaffrey in Round 1 and want to handcuff him with Guerendo. Maybe you're fading McCaffrey and are targeting Guerendo instead. Or maybe it's the middle-to-late rounds and you want a talented running back who's one injury away from a lot of touches. Guerendo wound up in that very spot last year, forced into action when McCaffrey and Jordan Mason got hurt in San Francisco. He did great, averaging 17.9 PPR points in four games he played at least 50% of the snaps in with 3.5 targets per game. Just be sure he is the backup to McCaffrey before you draft him -- the 49ers have fooled us with their depth charts before, but as of this writing no one else appears close to second-string. Guerendo will start getting picked in Round 8.

Guerendo, 24, is entering his second NFL season after playing a limited role off the bench for most of his rookie campaign. Granted, it was a small sample (99 touches), but the 2024 fourth-round pick was effective as both a rusher (5.0 YPC) and receiver (94% catch rate, 9.5 YPT). With Christian McCaffrey and Jordan Mason battling injuries, Guerendo played at least half the snaps in four games. In those weeks, he averaged 16.8 touches, 101.0 scrimmage yards and 17.9 fantasy points. The 49ers replaced Mason with Brian Robinson Jr. during the offseason, leaving Guerendo as a longshot to fantasy relevance. He'll only be worth adding should McCaffrey miss time and even then he may not be a starting option.

2025 Fantasy Football Rankings

Standard

#247

PPR

#230

Half-PPR

#247

Superflex

#186

2025 Fantasy Football Draft Projections

Rush Yds Rush TD Rec Rec Yds Rec TD
258.0 2.0 8.8 80.5 0.1

2025 Average Draft Position (ADP)

Standard

#165

Pick 14.09

PPR

#192

Pick 16.12

Half-PPR

#186

Pick 16.06

Superflex

#157

Pick 14.01

Injury Risk

Injury Risk:
Medium

Depth Chart

Strength of Schedule

Easy Season Ahead
1
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3
4
5
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7
8
9
10
11
12
13
Fantasy Playoffs
15
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18